Family-Based Bivariate Association Tests for Quantitative Traits

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Family-Based Bivariate Association Tests for Quantitative Traits

The availability of a large number of dense SNPs, high-throughput genotyping and computation methods promotes the application of family-based association tests. While most of the current family-based analyses focus only on individual traits, joint analyses of correlated traits can extract more information and potentially improve the statistical power. However, current TDT-based methods are low-...

متن کامل

Joint association analysis of bivariate quantitative and qualitative traits

Univariate genome-wide association analysis of quantitative and qualitative traits has been investigated extensively in the literature. In the presence of correlated phenotypes, it is more intuitive to analyze all phenotypes simultaneously. We describe an efficient likelihood-based approach for the joint association analysis of quantitative and qualitative traits in unrelated individuals. We as...

متن کامل

Improving the power of association tests for quantitative traits in family studies.

Association mapping based on family studies can identify genes that influence complex human traits while providing protection against population stratification. Because no gene is likely to have a very large effect on a complex trait, most family studies have limited power. Among the commonly used family-based tests of association for quantitative traits, the quantitative transmission-disequili...

متن کامل

Joint tests of linkage and association for quantitative traits.

In this paper we describe various study designs and analytic techniques for testing the joint hypothesis that a genetic marker is both linked to and associated with a quantitative phenotype. Issues of power and sampling are addressed. The distinction between methods that explicitly examine association and those that infer association by examining the distribution of allelic transmissions from a...

متن کامل

Family-based association tests for genomewide association scans.

With millions of single-nucleotide polymorphisms (SNPs) identified and characterized, genomewide association studies have begun to identify susceptibility genes for complex traits and diseases. These studies involve the characterization and analysis of very-high-resolution SNP genotype data for hundreds or thousands of individuals. We describe a computationally efficient approach to testing ass...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: PLoS ONE

سال: 2009

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0008133